Alright then must be just me then and the specs of my setup. I can't get it to work reliably on my XP, I have some weird unique conflict.
barebone and tweaked XP PRO SP1, P4 3GHz, 2GB of RAM, 2408mkII, GS 3.04.
Forgive me if you've done this already, but have you downloaded the latest driver from the MOTU website?
Also, is your Micro Express a parallel interface?
If so, there are settings that need to be adjusted in the Windows Device Manager and possibly the BIOS. It mentions this in the FAQ section of the MOTU website, I believe. These settings apply to all MOTU parallel interfaces.
Then again, if it is in fact a USB interface, then perhaps these settings need to be adjusted to suit that protocol, as well.