midi connection = 2-3ms latency right? so run your seq on one computer, then send 16 midi channels (live optional) to your sampling/vsti monster.
Havn't done this myself yet, but plan on linking my 2 machines via rewire and spdif connections. (one to feed another). i hopethis will work. You can always just use one to record the audio signal from your main pc.
Luckily I have a extra audiophile 2496, with spdif connection, can record digital at 24 bits...
ps.. what I really want to do is link 2 separate reasons.